Serotonergic Psychedelics Temporarily Modify Information Transfer in Humans

Serotonergic Psychedelics Temporarily Modify Information Transfer in Humans

BACKGROUND Psychedelics induce intense modifications in the sensorium, the sense of "self," and the experience of reality. Despite advances in our understanding of the molecular and cellular level mechanisms of these drugs, knowledge of their actions on global brain dynamics is still incomplete. Recent imaging studies have found changes in functional coupling between frontal and parietal brain ...

Psychedelics.

Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally considered physiologically safe and do not lead to dependence or addiction. Their origin predates written history, and they were employed by early cultures in many sociocultural and ritual contexts. After the virtually contempo...

Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics

Recent reports on the effects of psychedelic-assisted therapies for mood disorders and addiction, as well as the effects of psychedelics in the treatment of cluster headache, have demonstrated promising therapeutic results. In addition, the beneficial effects appear to persist well after limited exposure to the drugs, making them particularly appealing as treatments for chronic neuropsychiatric...

Extracellular potentials modify the transfer of information at photoreceptor output synapses in the blowfly compound eye.

Signal processing in fly photoreceptors and visual interneurons takes place with graded potentials. Photoreceptors drive large monopolar cells (LMCs) with synapses that, like their counterparts in vertebrates, have a high gain and introduce strong spatiotemporal antagonism (Laughlin et al., 1987) that implements predictive coding (Srinivasan et al., 1982). The synapses are contained in compartm...

Psychedelics and Religious Experience